中国ALK阳性NSCLC患者生活质量现状及专家洞见白皮书

三| HRQoL 及 PROM 在中国医生和 ALK 阳性 NSCLC 患者中的调查概况 中国 ALK 阳性 NSCLC 患者生活质量现状及专家洞见白皮书 中国临床肿瘤学会(CSCO)肿瘤支持与康复治疗专家委员会 2025 年 7 月 㧞| HRQoL ゑ PROM 䊻䐱⺛䄞㪛⼮ ALK 䂕㾵 NSCLC ⿝䎀䐱⭥⮘⥊ⶦ㌗ 䍦㑇᷉䐱㩞⫔䁈䐸㒗ⳡ䐯䐱㾥᷊ 㶖ㅽ㉝᷉⟗⤛䄞㋧⫔䁈⭻䄜⶞㭕䄞䊛᷊ ⿧䁳᷉䐱㩞⫔䁈䐸㒗ⳡ䐯䐱㾥 ᷊ 㝬⽋㘛᷉䎄ㅎ⫔䁈䄞䁈䊛⶞㭕㩼䄾ⴓ䄞䊛᷊ 塳䙜᷉⿋䐱㋧ゝ⫔䁈㵍イ䄞䁈䊛⶞㭕㵍イ䄞䊛᷊ ⺚㡅㩎᷉㩞Ⰼ㬂䐸㒗䄞䊛᷊ ⼯䐟䇣᷉ⶄㅉ㬂䐸㒗䄞䊛᷊ 㒖䈋㲳᷉䐱⺛䄞䁈㋧䁈䊛䐸㒗䄞䊛᷊ 㔿㯹㻝᷉⼴㚰㬂䐸㒗䄞䊛᷊ 㕎㧒᷉㑪㛟㬂䐸㒗䄞䊛᷊ 㝬䊟䅙᷉䐱⺛㋧ゝゝ㭖⫔䁈⶞㭕⭻䄜䄞䊛᷊ 㯯㻝᷉㩞㹘㬂䐸㒗䄞䊛᷊ 㰐㒛⿋᷉㚰⥞⫔䁈⭻䄜⶞㭕䄞䊛᷊ 㶕㆙㑝᷉䐱⺛㦬㘒ㆃ⳦㉝䓽䄞䊛᷊ 㾅㌝᷉䐱㚰⫔䁈㼇䁦ⱟ䄞䊛᷊ 䄇㸥㿄᷉㯥⪉㬂䐸㒗䄞䊛᷊ 䇻㡑㲯᷉⺄㹘䄞㋧⫔䁈⶞㭕䐸㒗䄞䊛᷊ 䍦⽍㗘᷉㋶㉝㉝䄞⫔䁈㹘㈊䄞䊛᷊ 䍵㉝᷉⡒㈊⫔䁈䐸㒗䄞䊛᷊ 䍵䁿㤐᷉⼴㚰㬂䐸㒗䄞䊛᷊ 䑘 ⢁ ⢁ 㸐 ⢁ 㸐 ᷉➕㾶㬰㝦㿓᷍㝦㘜⤜⳷㻩⽔᷊ 㧞| HRQoL ゑ PROM 䊻䐱⺛䄞㪛⼮ ALK 䂕㾵 NSCLC ⿝䎀䐱⭥⮘⥊ⶦ㌗ 㚠㔝 Contents 䄜᱃ 䍋 䄋..................................................................................................................................... 7 ⱟ᱃ 㣑䁵ᷛ㼏㚠⡔㈑ゑ㚠⭥...................................................................................................... 11 ᷉䄜᷊ ALK 䂕㾵 NSCLC ⭥ん⤂⶛⭄⼮䐯㑧㻷䓕 ........................................................... 11 1. 䐱⺛⳯➊䈌⳨㾂㻙⟜⳯➊᷉NSCLC᷊⭥ⳃ⤂㻷䓕䈌㒘㾱⤂䁈㲹䎘 .................. 11 2. ALK 䂕㾵 NSCLC ⭥㒘㾱⤂䁈㲹䎘䈌㑺⪓⢎㻷 ................................................... 11 3. ALK 䂕㾵 NSCLC ⭥䐯㑧㆙䍚䈌㑺⪓㬖ペ㻷䓕 ................................................... 11 4. ALK 䂕㾵 NSCLC ⭥ん⤂䈌㈎イ⶛⭄ ................................................................... 12 ᷉ⱟ᷊ ㅂ㋖㼁⹹㪛』䐫㑠᷉HRQoL᷊䊻 ALK 䂕㾵 NSCLC 䐯㑧䐱⭥䐹䄋㾵 ............. 13 1. HRQoL 㬨 ALK 䂕㾵 NSCLC 䓼⼰䐯㑧㚠⢋⭥⼬㾥䔊⧪ ..................................... 13 2. PROM 䊻 ALK 䂕㾵 NSCLC 䐱⭥䐈⧷䔘䇤䈌㬫䇤㾵 .......................................... 14 3. 䐱⺛⳯➊㒍䈓 HRQoL PROMs 䇇䇤⭥㚲⮄⼮㳕䍞 .............................................. 18 4. ⢁㾕⡟➸㠅㭊ⰵ䇻䐱⺛ ALK 䂕㾵 NSCLC ⿝䎀㑺⪓⹽㏎⭥䐹䄋㾵⼮䅃䅆 ...... 19 㧞᱃ HRQoL ゑ PROM 䊻䐱⺛䄞㪛⼮ ALK 䂕㾵 NSCLC ⿝䎀䐱⭥⮘⥊ⶦ㌗ ...................... 22 ᷉䄜᷊ ⮘⥊Ⳟⳉ ................................................................................................................... 22 㧞| HRQoL ゑ PROM 䊻䐱⺛䄞㪛⼮ ALK 䂕㾵 NSCLC ⿝䎀䐱⭥⮘⥊ⶦ㌗ 1. 㚠⢋㦬㦛⭥䁂䋒 ....................................................................................................... 22 2. ⮘⥊㸫㉎ ................................................................................................................... 24 3. 㵔ェⳞⳉ ................................................................................................................... 25 4. 㭞㈾㬶ゐ䈌䐫㑠㋹䐧 ............................................................................................... 25 ᷉ⱟ᷊ 㬽ⳤ䎀⭥〚⡟㾦㻃⼮䎐㑧㈎㏛ ............................................................................... 26 1. 㬽ⳤ䎀⭥〚⡟㦬㋻䁈㾦㻃 ....................................................................................... 26 2. 䄞㪛㼁⹹䎐㑧㈎䂊 ................................................................................................... 28 3. ⿝䎀㼁⹹䐯㑧㈎㏛ ................................................................................................... 29 4. 䄞㪛⼮⿝䎀䁂䋒 ALK-TKI ⭥㋝㑠䅓㯹 ................................................................. 30 ᷉㧞᷊ 䐱⺛䄞㪛⼮ ALK 䂕㾵 NSCLC ⿝䎀ⰵ䇻 HRQoL ゑ㡅 PROM ⭥㦰䐋⼮㲍Ⱙ .. 32 1. 䄞⿝ⰵ HRQoL ⭥㦰䐋⼮㲍Ⱙ ........................................