艾昆纬-心灵很重要：在印度引起人们对阿尔茨海默病的关注（英）

White PaperMind Matters: Shining the spotlight on Alzheimer’s Disease in India RUPANWITA GHOSH, Associate Medical Director, Medical Sciences and Strategy, IQVIA APACTable of contentsIntroduction 1Diagnosis of Alzheimer’s disease 2Management of Alzheimer’s disease 3Clinical research scope for India in Alzheimer’s disease 6Large patient population and genetic diversity 6Rising prevalence of Alzheimer’s disease in India 6Potential for biomarker research 7Cost-effectiveness 7Strengthened infrastructure and training 7Global data sharing 7Stable and favourable regulatory environment 7Linguistic and cultural diversity 8Caregiver roles and responsibilities 8English-speaking healthcare professionals 8Growing pharmaceutical industry 8Dementia clinical research in India 8Conclusion 9Acknowledgment 9Disclosures 9References 10About the authors 12iqvia.com | 1IntroductionFigure 1: Dementia cases by country: 2019 vs. projected 2050The prevalence of Alzheimer’s disease in India has become a growing concern today. As per recent data, Alzheimer’s disease prevalence in India is 7.4% among adults over the age of 60 — meaning about 8.8 million Indians are currently living with Alzheimer’s disease.1 By 2050, people over 60 years of age are predicted to constitute 19.1% of the total population. This alarming trend is attributed to various factors, including an aging population, reduced trends in fertility, increased life expectancy and evolving lifestyles.Worldwide, according to the Global Burden of Disease Study (GBDS) 2019 within the span of 2019-2050 the number of dementia cases will undergo a whopping increase of 166%, impacting the lives of ~152·8 million individuals; these estimates are similar to the predictions by WHO. Furthermore, this elevation in the number of dementia cases is projected to be highest (up to 330%) for countries like India that scale low on the Socio-Demographic Index (SDI). In 2019, India was the 4th largest contributor to the global burden of dementia and by 2050 it is expected to surpass Japan and USA to become the country with the 2nd largest number of dementia cases (next only to China) (Figure 1).2China20242025Dementia cases (in millions)251322.54.111.42015105IndiaUSAIndonesiaBrazilPakistanBangladeshRussiaMexicoJapan01.84.61.85.35.89.60.92.90.831.32.31.334.6 3.82 | Mind Matters: Shining the spotlight on Alzheimer’s Disease in India In this white paper, we strive to deep dive into the diagnostic and management trends for Alzheimer’s disease in India vis a vis the Western counterparts as well as look into the challenges India faces and the opportunities that India has to offer in the Alzheimer’s disease clinical research arena.Diagnosis of Alzheimer’s diseaseIn India, the diagnostic methods [patient’s family history, medical records, neuroimaging, cognitive tests, biomarkers, and laboratory tests (in order to rule out thyroid problems, metabolic issues, kidney disorders, anemia and vitamin B12 deficiency etc.) are similar to