艾昆纬-揭示见解：挖掘亚太地区肥胖临床试验的潜力-亚太十国调查（英）

White PaperUncovering Insights: Tapping into APAC’s Potential for Obesity Clinical Trials A Survey Across Ten Asia Pacific CountriesCECILIA SISON, MD, FPCP, FPSG, Medical Director, Medical Science and Strategy, Asia ENA LYN ANG, MD, FPCP, FPSG, Medical Director, Medical Science and Strategy, Asia CHARU GAUTAM, MBBS, MD, DNB, Senior Medical Director, Medical Science and Strategy, Asia SUJATA ROUTRAY, Clinical Planning Analyst, IQVIA APAC R&DSTable of contentsIntroduction 1Global status of obesity trials 2Objectives 2Methodology 2Results 4Investigator credentials and experience 4Epidemiology 4Patient pathway 5Diagnosis 5Management and treatment 7Clinical trial experience of participating investigators 9Discussion 9Conclusion 15Disclosure 15Acknowledgment 15References 16About the authors 20 iqvia.com | 1Obesity has become a global health problem. The global prevalence of obesity, defined as a body mass index (BMI) 25kg/m², is predicted to rise from 14% to 24% in 2020 and 2035, respectively. It is estimated that almost 2 billion will be affected by 2035.1In the Asia Pacific (APAC) region, obesity has also become a major public health concern with increasing prevalence rates. Australia has a high obesity prevalence of 31.3% based on an Australian National Health Survey in 2017–18.2 It is similar in New Zealand at 32.5%.3 In India, the prevalence of obesity is approximately 14% using a BMI cut-off for the Asian population (≥27.5 kg/m2).4 In South Korea, the overall prevalence of obesity (BMI ≥25 kg/m2) increased from 30.2% in 2012 to 38.4% in 2021, a 1.27-fold increase in 9 years.5 In Pakistan, World Health Organization (WHO) data indicates that 43.9% of the population is obese, and when Asian BMI cutoffs are applied, the prevalence is higher at 58.1%.6Among countries in Southeast Asia, Malaysia has the highest obesity prevalence rate of 33.7% using a BMI cut-off of ≥27.5 kg/m² and 19.7% with BMI of ≥30 kg/m².7 In Indonesia, the prevalence of obesity among all adults is 19.0% using the national obesity cut-off of BMI ≥27 kg/m2.8 In Thailand, approximately 19.0% were classified as class I obesity (BMI 25.0–29.9 kg/m2), and 4.8% as class II obesity (BMI ≥30.0 kg/m2).9 There was an increase in the prevalence of obesity in Vietnam from 10% in 2009 to 15% (male) and 16% (female) in 2015 based on a BMI ≥ 25 kg/m2.10 In the Philippines, the obesity prevalence in 2021 was 12.2% among females and 7.3% among males with BMI cutoff of >30kg/m².11 It is the opposite in Singapore wherein the prevalence of obesity was more common among males (13.1%) than females (10.2%) based on a National Population Health Survey in 2022.12 In terms of the latest country population data, India has the highest number of obese individuals, followed by Pakistan and Indonesia (Figure #1).IntroductionFigure 1: Prevalence of obesity in APAC38.4%33.7%58.1%n=148Mn=20Mn=12Mn=1.7Mn=8.4Mn=31Mn=17Mn=1.4Mn=23Mn=205M31.3%31.0%23.8%19.5%19.0%32.5%23.3%14.0%AustraliaIndonesia