2024都市人群科学护肝白皮书-BYHEALTHx庶正康讯x天猫

011.1 02011.2 051.3 10022.1 15132.2 162.3 172.4 192.5 25033.1 32313.2 34044.1 48474.2 494.3 521582. ™593. 614. 6401CHAPTER行01CHAPTERCHAPTERCHAPTER021.1.1 30020003002000300200020222302031.1 1.1.2 031.1.3 041.1.4 1.1.5 脸色发黄影响肝脏健康代谢变差脱发第二天没精神怕猝死黑眼圈头、脸出油月经失调体检肝指标偏高血管问题影响肾脏健康将军肚不担心熬夜影响其他情绪暴躁9.87%9.78%7.59%8.15%11.45%8.58%6.65%8.49%0.30%4.93%6.61%4.29%7.59%4.59%1.07%13.92%9.82%10.09%9.76%8.93%8.96%9.04%8.11%6.95%5.56%3.13%2.27%1.65%0.82%0.92%0.04%0.08%男性女性不同性别人群关注的健康问题侧重点不同图11-不同性别关注的健康问题相比之下，男性更担心肾脏健康、精气神、将军肚、肝指标等方面问题，女性则更关注脸色发黄、脱发、代谢变差等现象。 051.2 1.2.1 30020003002000061.2.2 071.2.2.1 1.2.2.2 081.2.3.1 1.2.3 091.2.3.2 101.2.3.3 1.3 NAFLD1.4 [1] 2023, 43(4) : 248-252. [2] Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030[J].Journal of Hepatology 2018 vol. 69 j 896–904.[3] The Global Burden of Liver Disease: The Major Impact of China[J].Hepatology. 2014 Decem-ber ; 60(6): 2099–2108. doi:10.1002/hep.27406.1302CHAPTERCHAPTERCHAPTERCHAPTER14152.1 2.1.1 2.1.2 162.2 2.2.1 172.2.2 2.3.1 2.3 182.3.2 B192.3.3 2.3.4 2.4 202.4.1 21222.4.2 232.4.3 2.4.4 242.4.5 2.4.6 252.5 262.5.1 272.5.2 282.5.3 2.5.4 2.6 [1] [2] Utoh R, Komori J, Kuge H, et al. Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruit-ment in the kidney. J Hepatol, 2018, 68(4): 744-753.[3] [4] [5] KONOPKAR J,BENZER S.Clock mutants of drosophila melano-gaster[J].Proc Natl Acad SciUS A,1971,68(9):2112-2116.[6] JAMES A A,EWER J,REDDY P,et al.Embryonic expressionof the period clock gene in the central nervous system of drosophilamelanogaster[J].EMBO J,1986,5(9):2313-2320.[7] Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P. PER2 controls lipid metabolism by direct regulation of PPAR. Cell Metab 2010; 12: 509-520.[8] Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 2012; 18: 1768-1777.[9] Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA. Rev-erb and Rev-erb coordinately protect the circadian clock and normal metabolic function. Genes Dev 2012; 26: 657-667.[10]Hernández-García J, Navas-Carrillo D, Orenes-Piñero E. Alterations of circadian rhythms and their impact on obesity, metabolic syndrome and cardiovascular diseases. Crit Rev Food Sci Nutr 2020; 60: 1038-1047.[11] VllanuevaJE,Livelo C,Truijllo AS,Chandran S,Woodworth B,Andrade L,Le HD,ManorU,Panda S,Melkani GC.Time-restrict-ed feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.Nat Commun 2019;10:2700. [12]Schäbler S,Amatobi KM,HornM,Rieger D,Helf rich-Förster C,Mueller MJ,Wegener C,Fekete A.Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibil